2023.06.01 18:14 hornoquenoanda Estoy en plena Crisis. Noto que mi pareja tiene los “huecos” intimos muy dilatados y yo no hice uso de ellos, pienso lo peor. AYUDA.
2023.06.01 18:11 Visible_Kitchen4722 A New York, des bureaux largement dépeuplés en fin de semaine
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2023.06.01 17:44 shallah New York City Jails No Longer Announcing Deaths After Horrifying Wave Of Fatalities The Department of Correction says that the de Blasio-era practice of notifying the press when someone dies in a detention facility is over.
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2023.06.01 16:06 Wild-Ordinary-298 Queens 10k 2023 Route
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2023.06.01 15:56 zeruel01 opcion Pagare Citibanamex a 12 y 13% anual
![]() | que tal justamente sin deudas ahorita tengo algo de dinero que se me esta acumulando x ser 250k+ masterace mas de 500k y me afecta mentalmente tenerlo ahi quieto ganas de gastarlo(en crypto) no se me quitan submitted by zeruel01 to MexicoFinanciero [link] [comments] tengo pendiente la compra de una propiedad o un vehiculo de trabajo pero por mientras siento que es mucho rollo moverlo a cetes para sacarlo en 30 dias asi que justamente les comparto esta opcion que al parecer levanta mas que cetes asumo por 84 dias a 12/13% en lo que junto otros 500 podria ser la mejor opcion y lo comparto por si alguien esta en la misma situacion que opinan ? mejor que cetes y pues sin hacer tanto desmadre vere si hoy en la noche lo subo https://preview.redd.it/2kjno8lbwe3b1.png?width=933&format=png&auto=webp&s=ae986295e11607a1302e2ef35aba9daa133c16e4 |
2023.06.01 15:55 autotldr Gov. Ron DeSantis' 2022 reelection dollars financing White House run violates FEC rules, watchdog alleges
Florida Gov. Ron DeSantis' presidential bid is facing scrutiny after a nonprofit watchdog filed a complaint against his campaign for allegedly trying to repurpose millions in unspent funds from his 2022 reelection to support a White House run.
The complaint centers on the former Friends of Ron DeSantis PAC, which raised hundreds of millions for the governor when he was seeking a second term.
The leftover $80 million was left unspent after election night, until recently when DeSantis cut ties with the PAC. The PAC then changed its name to Empower Parents and according to the New York Times supposedly was ready to funnel funds to the DeSantis 2024 Super PAC Never Back Down.
Never Back Down and Empower Parents didn't offer any immediate response to the allegations made by the CLC. However, state Sen. Blaise Ingoglia, R-Spring Hill, who chairs the former DeSantis PAC, recently told us leftover money from Empower Parents couldn't touch the White House run.
"It's a state PAC. So, the only thing that we can do with it is back state candidates or anybody that falls under a state election, so that's your local school board, county commissioner, legislative office."
The latest Empower Parents finance data from May 25 shows a contribution of $1 million to a similarly named PAC run by current Florida House Speaker Paul Renner.
2023.06.01 15:47 OneCryptographer4005 (38) Minha profissão vai se tornar obsoleta
2023.06.01 15:25 WilsonTeresa223 [HIRING] 25 Jobs in NY Hiring Now!
2023.06.01 15:10 No_Competition4897 [HIRING] 25 Jobs in NY Hiring Now!
2023.06.01 14:47 ZangdokPalri A talk based on Prajnaparamita Sutra (25k Lines) in celebration of the Buddha's birth, awakening, and parinirvana - Sun Jun 4 @ 9AM EDT
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2023.06.01 14:25 Zentaurios BRC-721E and Changes for Crypto Exchanges - ZentaNews 6–1–2023
![]() | What is BRC-721E? T-Mobile parent company becomes validator on Polygon and centralized exchanges continue to struggle with regulations. #ZentaNews #BRC721E #Polygon #Binance #DebtCeiling submitted by Zentaurios to zentanews [link] [comments] Original news stories on Zentaurios.app https://reddit.com/link/13xg8hu/video/jwaf9xa4ge3b1/player Ordinals Market And Bitcoin Miladys Launched New Standard BRC-721E According to the official website, the Bitcoin NFT market Ordinals Market and Bitcoin Miladys jointly released the BRC-721E standard, allowing immutable, verifiable ERC-721 NFTs to be migrated to Ordinals … BRC-721E Token Standard Bridges Ethereum NFTs to Bitcoin Ordinals BRC-721E Token Standard Bridges Ethereum NFTs to Bitcoin Ordinals A new blockchain token standard is allowing traders to convert their Ethereum-based non-fungible tokens (NFTs) to Ordinals, or NFTs on the… T-Mobile’s Parent Company Becomes Validator on Polygon (MATIC) NetworkThe parent company of one of the biggest cell service providers in the US is becoming a validator on layer-2 scaling network Polygon (MATIC). In a new company announcement, Deutsche Telekom, the conglomer…Regulation and Centralized ExchangesCrypto Exchange Binance to Remove Privacy Coins From 4 European MarketsMultiple reports have revealed that Binance, the crypto exchange with the highest trade volume, has announced the removal of 12 privacy-focused cryptocurrencies from its markets in Spain, France, Poland, a… Bybit Follows Binance’s Footsteps, Exits Canadian Market Amid Regulatory Concerns In the wake of Binance’s departure from Canada, cryptocurrency exchange Bybit has announced its exit from the nation as well, citing “recent regulatory development” as the reason. Effective May 31,… read m… US court says IRS has legal authority to access Coinbase users’ trading data The court stated trading records at Coinbase are akin to financial records at a bank and cannot be protected under constitutional rights…. Coinbase CEO Warns China Will Dictate Global Digital Finance Coinbase CEO, Brian Armstrong, has warned about the threat posed by China’s increasing dominance in the cryptocurrency and fintech industry. … Politics and International Crypto NewsBitcoin Soars $28,000 After US Debt Ceiling Lift Ready To VoteBitcoin’s weekly situation update showed positive signs, with the price surpassing the $28,000 threshold after the agreement to raise the debt ceiling was announced and voted on. After seeing the positive … Elizabeth Warren highlights crypto’s role in fentanyl trade; plans to combat with bill The U.S. senator intends to reintroduce her Digital Asset Anti-Money Laundering Act…. Proposed Texas Bill Limiting Bitcoin Miners’ Grid Participation Halted in Committee In a significant development for the crypto industry, a Texas bill proposing to limit Bitcoin miners’ participation in cost-saving grid programs was halted in a state House of Representatives committee… Laos Leverages Blockchain Technology in Its Drive Towards Digital Transformation In an ambitious move toward digital evolution, the Laos government has reportedly prioritized blockchain technology as a vital part of its digital transformation strategy1. Spearheaded by Laotian Prime Min… Jimbos Protocol turns to law enforcement after hacker ignores $800K bounty The DeFi project has contacted the Department of Homeland Services (DHS). Jimbos Protocol is now offering the bounty to the general public, meaning that anyone who provides information leading to an arrest or the recovery of funds can receive the reward. The team previously ann… Crypto Market NewsBiggest Movers: SHIB Nears 6-Month Low, Whilst LTC Drops by 4% on WednesdayShiba inu moved closer to a six-month low on Wednesday, as sentiment in cryptocurrency markets shifted bearish. Litecoin was another notable token to fall, slipping by over 4% today. The… read more:… Stablecoin Economy Reaches 20-Month Low as BUSD Redemptions Surpass 10 Billion Tokens in 3 Months Three months have passed since Paxos made the decision to cease the production of new BUSD tokens, complying with the directive issued by the New York Department of Financial Services… NFT NewsANA and ANA NEO’s Novel Move: A Revolutionary NFT Marketplace for the Airline IndustryIn an exciting development, All Nippon Airways (ANA), in collaboration with ANA NEO, made a groundbreaking stride in the aviation industry on May 30, 2023… NFT artist allegedly battling cancer revealed to be scam The Pixel Penguins NFT scammer made over $100,000 from the scheme and immediately deactivated their Twitter account…. Junkineering Launches a Closed Demo in Q3 2023: New Approach Vision for the Web3 Gaming Industry What is wrong with the current P2E market Since most P2E projects do not create long-playing products, the Free-to-Play model of the past decade is breaking down, threatening to disrupt… A Flower Lost in TimeFlorian is a flower who loves to travel through time. He visits the Cretaceous period and gets stuck there when his clock malfunctions. He panics but decides to explore his new environment and learn from i…#ZentaPost #ZentaNews #ZentaNewsDesk #Zentagram #ZentauriosOriginal news stories on Zentaurios.app Ordinals Market And Bitcoin Miladys Launched New Standard BRC-721E According to the official website, the Bitcoin NFT market Ordinals Market and Bitcoin Miladys jointly released the BRC-721E standard, allowing immutable, verifiable ERC-721 NFTs to be migrated to Ordinals … BRC-721E Token Standard Bridges Ethereum NFTs to Bitcoin Ordinals BRC-721E Token Standard Bridges Ethereum NFTs to Bitcoin Ordinals A new blockchain token standard is allowing traders to convert their Ethereum-based non-fungible tokens (NFTs) to Ordinals, or NFTs on the… T-Mobile’s Parent Company Becomes Validator on Polygon (MATIC) NetworkThe parent company of one of the biggest cell service providers in the US is becoming a validator on layer-2 scaling network Polygon (MATIC). In a new company announcement, Deutsche Telekom, the conglomer…Regulation and Centralized ExchangesCrypto Exchange Binance to Remove Privacy Coins From 4 European MarketsMultiple reports have revealed that Binance, the crypto exchange with the highest trade volume, has announced the removal of 12 privacy-focused cryptocurrencies from its markets in Spain, France, Poland, a… Bybit Follows Binance’s Footsteps, Exits Canadian Market Amid Regulatory Concerns In the wake of Binance’s departure from Canada, cryptocurrency exchange Bybit has announced its exit from the nation as well, citing “recent regulatory development” as the reason. Effective May 31,… read m… US court says IRS has legal authority to access Coinbase users’ trading data The court stated trading records at Coinbase are akin to financial records at a bank and cannot be protected under constitutional rights…. Coinbase CEO Warns China Will Dictate Global Digital Finance Coinbase CEO, Brian Armstrong, has warned about the threat posed by China’s increasing dominance in the cryptocurrency and fintech industry. … Politics and International Crypto NewsBitcoin Soars $28,000 After US Debt Ceiling Lift Ready To VoteBitcoin’s weekly situation update showed positive signs, with the price surpassing the $28,000 threshold after the agreement to raise the debt ceiling was announced and voted on. After seeing the positive … Elizabeth Warren highlights crypto’s role in fentanyl trade; plans to combat with bill The U.S. senator intends to reintroduce her Digital Asset Anti-Money Laundering Act…. Proposed Texas Bill Limiting Bitcoin Miners’ Grid Participation Halted in Committee In a significant development for the crypto industry, a Texas bill proposing to limit Bitcoin miners’ participation in cost-saving grid programs was halted in a state House of Representatives committee… Laos Leverages Blockchain Technology in Its Drive Towards Digital Transformation In an ambitious move toward digital evolution, the Laos government has reportedly prioritized blockchain technology as a vital part of its digital transformation strategy1. Spearheaded by Laotian Prime Min… Jimbos Protocol turns to law enforcement after hacker ignores $800K bounty The DeFi project has contacted the Department of Homeland Services (DHS). Jimbos Protocol is now offering the bounty to the general public, meaning that anyone who provides information leading to an arrest or the recovery of funds can receive the reward. The team previously ann… Crypto Market NewsBiggest Movers: SHIB Nears 6-Month Low, Whilst LTC Drops by 4% on WednesdayShiba inu moved closer to a six-month low on Wednesday, as sentiment in cryptocurrency markets shifted bearish. Litecoin was another notable token to fall, slipping by over 4% today. The… read more:… Stablecoin Economy Reaches 20-Month Low as BUSD Redemptions Surpass 10 Billion Tokens in 3 Months Three months have passed since Paxos made the decision to cease the production of new BUSD tokens, complying with the directive issued by the New York Department of Financial Services… NFT NewsANA and ANA NEO’s Novel Move: A Revolutionary NFT Marketplace for the Airline IndustryIn an exciting development, All Nippon Airways (ANA), in collaboration with ANA NEO, made a groundbreaking stride in the aviation industry on May 30, 2023… NFT artist allegedly battling cancer revealed to be scam The Pixel Penguins NFT scammer made over $100,000 from the scheme and immediately deactivated their Twitter account…. Junkineering Launches a Closed Demo in Q3 2023: New Approach Vision for the Web3 Gaming Industry What is wrong with the current P2E market Since most P2E projects do not create long-playing products, the Free-to-Play model of the past decade is breaking down, threatening to disrupt… A Flower Lost in TimeFlorian is a flower who loves to travel through time. He visits the Cretaceous period and gets stuck there when his clock malfunctions. He panics but decides to explore his new environment and learn from i…#ZentaPost #ZentaNews #ZentaNewsDesk #Zentagram #Zentaurios |
2023.06.01 14:09 911one87 WNBA Picks 01/06/2023
2023.06.01 13:54 transcribersofreddit BrandNewSentence Image "New York fertility doctor accused of using own sperm dies when hand-built plane crashes"
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2023.06.01 13:48 Additional_Gate_5478 [Discussion] iPhone 6s running pmOS with xfce4 (Firefox and xfce4-terminal opened)
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2023.06.01 13:07 rusticgorilla Florida jail officials refuse heart transplant recipient his medication, causing his death; DOJ says Louisiana officers violated law in death of autistic teen
“I am on medication,” Barry told the judge. “I just had a heart transplant, and I haven’t taken my medicine all day since I have been locked up, and I take rejection medicines for my heart so my heart won’t reject it, and I’m almost two years out.”Barry also told jail officials while in police custody; they made note of it, but never gave him the drugs.
The medical records, initially obtained by Jacksonville civil rights attorney Andrew Bonderud, show that Barry also told the jail’s healthcare providers about his medications. Barry only received his blood pressure medicine and a drug for cholesterol and his prostate, according to the medicine log.Barry died at home three days after being released, having missed at least five doses of the anti-rejection medication.
Bonderud said he believes the jail not giving Barry his anti-rejection medicine “was entirely driven by profit and a profit motive.” Bonderud, who is representing Barry’s family, explained, “Generic cholesterol medication probably isn’t that expensive. But the heart transplant medicine is very expensive.”
Dr. Maya Guglin, an Indiana cardiologist on the board at the American College of Cardiology, said organ transplant recipients have to take anti-rejection medications because their bodies view the new organ as an invasion that must be fought off.
“If you just drop those medications, everyone is eventually going to reject that organ,” she said.
Even if medication is restarted, it will be too late, Guglin said.
“Prior to arriving at the Plaintiffs’ location, Sheriff’s deputies failed to plan, choosing instead to ride in like cowboys from a John Wayne movie, defaulting to using deadly force, immediately, without attempting to deescalate the situation, in complete disregard for State law/regulation, Sheriff’s policies, and/or County ordinances,” the lawsuit states.York County Sheriff Kevin Tolson has defended the deputies’ actions, claiming that Mullinax picked up the shotgun in his truck and the officers feared for their lives. Three of the deputies who shot Mullinax are still on duty.
According to court documents, the deputies fired almost 50 rounds at Mullinax, striking him approximately nine times, including in the head. The plaintiffs’ attorneys allege this happened despite Beason being in the line of fire and Mullinax having both his arms raised.
“I tell all of my deputies that their goal is to serve the citizens of York County and then to go home safely to their families. Mr. Mullinax chose to put these men in danger by pulling a shotgun. These deputies responded appropriately to the threat as they were trained to do. Had Mr. Mullinax made different choices that day, deputies would not have been required to use force,” said Sheriff Kevin Tolson. “Our ultimate goal is to ensure the safety of the public and our deputies. Regardless of the outcome of this lawsuit, we want to reassure our residents that we will continue to provide high quality and professional law enforcement service.”Mullinax survived numerous gunshot wounds, including three to his head. After shooting him, the department charged Mullinax with allegedly pointing a gun at them.
Plaintiff Mullinax, who somehow miraculously survived the horrific shooting, has maintained his innocence of the criminal charges brought by Sheriff’s deputies. Plaintiff Mullinax denies pointing, brandishing, or presenting a firearm in any threating manner at Sheriff’s deputies, and Plaintiff Beason, who was present and standing directly beside the vehicle in plain view of Plaintiff Mullinax, maintains Plaintiff Mullinax did not point, brandish, or present a firearm in any threating manner at Sheriff’s deputies.
E.P. began to slap himself in the head, a behavior which is a common physical trait for many persons on the Severe Autistic Spectrum Disorder and is a readily observable manifestation of the person’s disability and anxiety.During this outburst, Parsa began physically struggling with his dad. The manager of the laser tag venue called the police to report there was “a man with his autistic child…in a confrontation” in the parking lot.
Along with other repetitive motions, this repetitive head slapping is sometimes referred to as type of “stimming” and can be an attempt by the person with autism to calm themselves when confronted with frustration, anxiety and/or inability to communicate. It can also be used by the individual as a self-calming or self-soothing technique to try to avert or mitigate the severity of an outburst or as self-injurious behavior. It is a visible sign that the person may be experiencing or is about to experience an outburst.
The physical restraint of E.P. in JPSO custody began with a 6’3”, very large, over 300-pound deputy taking E.P. to the ground, striking him and then sitting on E.P.’s back, holding him face down, for approximately seven minutes. Eventually there were a total of seven JPSO deputies involved, sitting on, handcuffing, shackling, holding down, or standing by E.P. as he was restrained and held face down on his stomach against the hard surface of the parking lot. The final application of excessive force against E.P. involved a deputy using his forearm to place a choke/neck hold around E.P.’s head, shoulder and neck, as he lay in a prone position, with a deputy on his back, and other deputies holding down his arms and legs, while he was handcuffed and in leg shackles.Jefferson Parish Sheriff’s deputies sat on Parsa for more than nine minutes, only releasing him after “his body had gone limp and he had urinated on himself.”
9 minutes and 6 seconds. This is how long this extremely dangerous, lifethreatening and forceful prone restraint, involving the use of the deputies’ body weight and holds, mechanical restraints, choke/neck hold, following a period of physical exertion, was applied to an unarmed, obese 16-year-old severely autistic child in the midst of a sensory outburst or meltdown.Parsa was taken to a hospital and pronounced dead. His parents filed a lawsuit against the Sheriff’s office, arguing that the deputies violated Parsa’s First, Fourth, Ninth, and Fourteenth Amendment rights, as well as the Americans with Disabilities Act.
During that 9 minutes and 6 seconds, there were several clear and distinct opportunities, when E.P. was secured, was calm, was not actively resisting, when the JPSO deputies failed to de-escalate, failed to appropriately reduce the use of force against E.P., and failed to intervene to prevent the use of excessive force by other deputies.
Once E.P. was handcuffed, they did not roll him onto his side. They did not sit him up or stand him up. They did not secure him in a vehicle. They did not continuously monitor him. Instead, they continued to hold him face down, on his belly, while applying unreasonable and excessive force, resulting in his death. It wasn’t until his body had gone limp and he had urinated on himself that the deputies rolled him into “recovery position.” By then it was too late
Here, the record is replete with facts showing that several Defendants knew about E.P.'s disability before or on arrival to the scene and that others learned of his disability during the encounter…Plaintiffs have also put forth evidence that the deputies, who knew they were responding to a call for assistance with a child experiencing a behavioral health crisis, used force inappropriately to respond to a child’s known disability-related behavior…
Critically, nothing in the briefing suggests that E.P. had a weapon, that officers ever reasonably suspected he had a weapon, or that there was a threat to human life… because abundant facts show that Defendants were on notice of E.P.’s disability, a reasonable jury could conclude that Defendants should have reasonably modified their procedures in restraining E.P.
2023.06.01 13:04 fixefete USA Party mit BBQ – rauchig, saftig und so lecker🥰!
![]() | Ab nach Amerika. Schon gehört? In den USA befindet sich das absolute BBQ Paradies. Kein Steak bleibt am Grill zurück, kein Pulled Pork wird verschwendet. Krautsalat gibt es mit dazu, natürlich flankiert von gegrillten Maiskolben und einem kühlen Bier. Sobald sich die Magennerven von Familie und Freunden beruhigt haben, schwingt in deiner USA Party das schöne Flair von endlosen Weiten und tollen Momenten mit. Ob auf Hawaii oder in New York – die Vereinigten Staaten von Amerika heißen dich willkommen! submitted by fixefete to partydekofixefete [link] [comments] Länderparty USA – bald ist Independence Day🇺🇸 Am 4. Juli ist es soweit. In allen Bundesstaaten wird der Unabhängigkeitstag gefeiert. Lade deine Lieben ein, plane eine Grillparty unter freiem Himmel und besorge grillbare Köstlichkeiten. Coole „Stars and Stripes“ Accessoires und USA Deko schmücken deine Partyzone. Es gibt Spare Rips, Burger, Würstchen und Fries. Feiere das Leben und deine Unabhängigkeit! Ganz Amerika feiert mit dir! USA Party Deko für dich🤩 Typisch amerikanische Party Deko mit Streifen, Sternen, Flaggen und in Rot-Weiß-Blau. Hol dir echte Originale. Schöne USA Partydeko Inspirationen haben wir hier für dich 👉👉👉 www.fixefete.de/laenderparty-amerika-usa USA Party Deko BBQ Grillparty |
2023.06.01 11:40 Dowdidik En Juin, on explore l'intérieur ! - Venez parler des psychédéliques durant tout le mois !
![]() | submitted by Dowdidik to AddictionsFR [link] [comments] Bicycle day Cela va bientôt être la saison des concerts en extérieur, des festivals, et du temps idéal pour flâner dehors. Et on sait très bien que ce sont des conditions idéales pour beaucoup de consommer des psychédéliques ! Peut-être l’expérience de la drogue porte-t-elle des fruits significatifs lorsqu’elle est enracinée dans le sol d’un esprit mûr et cultivé. Mais cette expérience a soudain été saisie par une génération de jeunes qui sont pathétiquement a-culturels et qui n’apportent souvent rien d’autre à l’expérience qu’un désir vide. Dans leur rébellion adolescente, ils se sont débarrassés de la culture corrompue de leurs aînés et, avec cette eau de bain souillée, du corps même de l’héritage occidental, au mieux en faveur de traditions exotiques qu’ils ne comprennent que marginalement, au pire en faveur d’un chaos introspectif dans lequel les dix-sept ou dix-huit années de leur vie non formée flottent comme des atomes dans le vide. Qu’est-ce qu'un psychédélique ?Tous les psychédéliques stimulent directement un sous-type particulier de nos récepteurs de sérotonine ; il s’agit des récepteurs 5HT2A, qui jouent un rôle important dans les fonctions cérébrales supérieures. L’effet le plus connu est la production de visuels inhabituels – pas de véritables hallucinations (qui sont des images sans fondement dans la réalité), mais des distorsions étranges et des ajouts imaginatifs aux images des choses physiquement présentes. Ces phénomènes peuvent se produire aussi bien les yeux ouverts que les yeux fermés. Les drogues psychédéliques sont également empathogènes – elles créent des sensations d’attention, d’amour et de connexion avec d’autres personnes et avec le monde naturel.Le terme psychédélique signifie “manifestation de l’esprit”, ce qui sert à imager l’introspection associée à la consommation de ces substances. Cette définition pourrait laisser penser à bien d’autres drogues que les psychédéliques auxquels on associe souvent le terme, il est donc important de noter que ce terme réfère dans la recherche scientifiques aux substances agissant directement sur les récepteurs 5HT2A. Il faut dans cette optique prendre aussi en compte la MDMA et la kétamine, qui ne sont pas des psychédéliques classiques mais ont bel et bien une action que l’on peut qualifier de psychédélique. Compte tenu de l’utilisation historique répandue des psychédéliques comme sacrements dans une variété d’autres cultures, la définition de Jérôme Jaffe en 1990 pour la classe des psychédéliques peut peut-être être appréciée : …la caractéristique qui distingue les agents psychédéliques des autres classes de drogues est leur capacité à induire de manière fiable des états de perception, de pensée et de sentiment altérés qui ne sont pas expérimentés autrement, sauf dans les rêves ou dans les moments d’exaltation religieuse.L’un des pionniers de la recherche sur le LSD, Daniel Freedman, a noté que …une dimension fondamentale du comportement… révélée de manière convaincante dans les états de LSD est le ‘présage’ – la capacité de l’esprit à voir plus qu’il ne peut dire, à expérimenter plus qu’il ne peut expliquer, à croire et à être impressionné par plus qu’il ne peut justifier rationnellement, à expérimenter l’illimité et les événements ‘sans limites’, du banal au profond.Freedman DX. (1968) On the use and abuse of LSD. Arch Gen Psychiatry 18:330–347. L’utilisation des psychédéliques comme élément central de nombreuses pratiques religieuses, ainsi que les effets psychopharmacologiques profonds et uniques suggérés par la définition de Jaffe et les observations de Freedman, permettent de prendre conscience que les psychédéliques constituent une catégorie à part entière de substances altérant l’esprit. En effet, cette connaissance a incité Carl Ruck et ses collègues en 1979 à inventer le mot enthéogène pour remplacer les termes hallucinogène et psychédélique, qu’ils considéraient tous deux comme ayant des connotations négatives. L’enthéogène est dérivé des racines grecques entheos, qui signifie “Dieu (theos) à l’intérieur”, et genesthe, qui signifie “générer”. Le mot enthéogène désigne donc essentiellement une substance ou un matériau qui génère Dieu ou le divin en quelqu’un. Bien qu’il semble peu probable que le terme enthéogène soit adopté par la communauté scientifique officielle, il est intéressant de savoir que dans certains cercles enthéogène est synonyme de psychédélique. De plus, il faut savoir que les effets produits par les psychédéliques (nous pourrions même dire des drogues en général) dépendent fortement de la disposition mentale individuelle et du contexte d’usage. C’est le set & settings. Il est important de penser à plusieurs choses : se connaître ainsi que ses limites, être bien entouré ou tout du moins dans un environnement suffisamment sécurisé sur le plan psychologique, connaître les produits et anticiper les potentiels problèmes pouvant survenir. L’usage de drogue n’est jamais anodin, et il est important de prendre en compte de nombreux paramètres si l’on veut pouvoir en profiter le plus longtemps possible et dans la meilleure des santés possible ! Ce qu’il est important de savoir.Pendant des décennies, les médias ont largement dépeint les psychédéliques comme des drogues extrêmement dangereuses ; en fait, les psychédéliques sérotoninergiques classiques sont généralement considérés comme très sûrs sur le plan physiologique par rapport aux opiacés et aux psychostimulants, comme on peut le voir iciBonomo, Y., Norman, A., Biondo, S., Bruno, R., Daglish, M., Dawe, S., … Castle, D. (2019). The Australian drug harms ranking study. Journal of Psychopharmacology, 026988111984156. doi:10.1177/0269881119841569 Néanmoins, malgré la sécurité physiologique relative des psychédéliques, ils peuvent entraîner de graves conséquences psychologiques. Ces substances n’entraînent pas (ou très peu) d’accoutumance ou de dépendance et ne semblent pas impliquer de renforcement lié à l’usage. Cela est compréhensible quand on sait que les hallucinogènes sérotoninergiques n’ont pas d’effets directs sur les systèmes dopaminergiques du cerveau, une pharmacologie qui semble essentielle pour presque toutes les drogues pouvant engendrer une dépendance. La consommation de fortes doses de psychédéliques peut entraîner des problèmes vasculaires car le récepteur 5-HT2A est associé à la contraction des muscles lisses vasculaires, à l’agrégation plaquettaire, à la formation de thrombus et aux spasmes des artères coronaires. La vasoconstriction aiguë provoquée par la sérotonine est généralement partagée par l’activation des récepteurs 5-HT1B et 5-HT2A ; cependant, dans les artères intracrâniennes, seul le récepteur 5-HT1B est le médiateur de la constriction. L’administration répétée de psychédéliques entraîne un développement très rapide de la tolérance, connu sous le nom de tachyphylaxie, un phénomène qui résulterait de la régulation négative des récepteurs 5-HT2A. L’administration quotidienne de LSD entraîne essentiellement une perte totale de sensibilité aux effets de la drogue au quatrième jour. De même, chez l’homme, l’administration quotidienne de l’amphétamine hallucinogène 2,5-diméthoxy-4-méthylamphétamine (DOM) entraîne une tolérance importante aux effets de la drogue au troisième jour. Chez les humains, une tolérance croisée se produit entre la mescaline et le LSD et entre la psilocybine et le LSD. Les substances que l’on retrouve dans la catégorie des psychédéliques :
Luethi, D., Liechti, M.E. Designer drugs: mechanism of action and adverse effects. Arch Toxicol 94, 1085–1133 (2020). https://doi.org/10.1007/s00204-020-02693-7 N'hésitez pas à partager vos expériences, à poser vos questions, et à rajouter des informations qui vous sembleraient importantes ! Prenez soin de vous. Aller plus loin sur les psychédéliques :Papiers scientifiques :
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2023.06.01 11:03 debik229 Why didn't US and Canada build a bridge like this, are they too poor?
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2023.06.01 08:47 ta_f_a Streak 3x: Una noche tranquila
2023.06.01 08:47 jnel69420 I made a college park tour "news article"
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2023.06.01 08:30 Sailor_Mnemosyne ¿Te has salvado de un secuestro/secta/asalto? ¿Como?
2023.06.01 07:41 burgerburglar Streak 40: Un día divertido